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EISSN: 2313-3724, Print ISSN:2313-626X

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 Volume 4, Issue 12 (December 2017), Pages: 125-132


 Review Paper

 Title: A review of human genome project (HGP) from ethical perspectives

 Author(s): Engku Ahmad Zaki Engku Alwi 1, Norazmi Anas 2, *, Zakiah Samori 3, Zuriani Yaacob 4, Wan Rohani Wan Taib 5, Mohd Hudzari Razali 6, Syarilla Iryani Ahmad Saany 7


 1Faculty of Islamic Contemporary Studies, Universiti Sultan Zainal Abidin, Terengganu, Malaysia
 2Academy of Contemporary Islamic Studies, Universiti Teknologi MARA, Perak Branch, Tapah Campus, Perak, Malaysia
 3Academy of Contemporary Islamic Studies, Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia
 4Academy of Language Studies, Universiti Teknologi MARA, Pahang Branch, Raub Campus, Pahang, Malaysia
5Institute for Community [Health] Development, Universiti Sultan Zainal Abidin, Terengganu, Malaysia
 6Faculty of Plantation and Agrotechnology, Universiti Teknologi MARA, Melaka Branch, Jasin Campus, Melaka, Malaysia
 7Academic Quality and e-Learning Centre, Universiti Sultan Zainal Abidin, Terengganu, Malaysia

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The human genome is the collection of DNA in the nucleus of human cells. It contains twenty-three pairs of chromosomes and serves as identification marks or blueprints. These distinct structures differentiate humans from other living organisms such as microorganisms, flora, and fauna. Despite this groundbreaking increase in human genetics knowledge, it has led to the emergence of complex ethical, legal and social issues particularly related to the Human Genome Project (HGP). Therefore, this paper intends to provide much deeper insights into the study of concepts, applications of modern genetics and human genetics issues that may arise in contemporary society and the Human Genome Project from ethical perspective in science. Apparently, this study employed descriptive literature review and the results show that the Human Genome Project has significantly increased the level of understanding of the basic damage or genetic defects, the structure of DNA, the identification of the position of all genes and human genome databases as well as HGP major contributions in the field of biology specifically in developmental biology and neurobiology. This indicates that the Human Genome Project has opened up a new era in modern biotechnology that may improve life quality of mankind. Nevertheless, the newfound genetic knowledge or any HGM-related research should be based on ethics known as ELSI (Ethical, Legal and Social Implications) so that it does not damage the population and the descendants of the human beings. 

 © 2017 The Authors. Published by IASE.

 This is an open access article under the CC BY-NC-ND license (

 Keywords: HGP, ELSI, Human Genetic

 Article History: Received 7 August 2017, Received in revised form 12 October 2017, Accepted 13 October 2017

 Digital Object Identifier:


 Engku Alwi EAZ, Anas N, Samori Z, Yaacob Z, Taib WRW, Razali MH,  and Saany SIA (2017). A review of human genome project (HGP) from ethical perspectives. International Journal of Advanced and Applied Sciences, 4(12): 125-132

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