International Journal of Advanced and Applied Sciences

Int. j. adv. appl. sci.

EISSN: 2313-3724

Print ISSN: 2313-626X

Volume 3, Issue 9  (September 2016), Pages:  103-109

Title: Antihypertensive effects of edible brown seaweeds in rats

Author(s):  Faezah Sabirin 1, 2, *, Khoo Kong Soo 3, Hoe See Ziau 1, Lam Sau Kuen 1


1Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
2Centre of Preclinical Science Studies, Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, 47000 Sungai Buloh Selangor, Malaysia
3Department of Chemical Science, Faculty of Science, University Tunku Abdul Rahman, 31900 Kampar, Perak, Malaysia

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The present study is focused to evaluate the effect of three different brown seaweeds on blood pressure and heart rate (HR) using spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats.  The seaweeds, Turbinaria ornata (T. ornata), Sargassum species (Sargassum sp.) and Padina tetrastromatica (P. tetrastromatica), were extracted in cold water and freeze-dried. Anaesthetised rats were prepared for direct blood pressure measurements with the changes in HR also being monitored. Rats were administered intravenously with the aqueous extract of the seaweeds at doses of 2.5 to 20.0 mg/kg.  Concentrations of Na+, K+, Ca2+ and Mg2+ found in the dose of 20.0 mg/kg of the marine plant extracts were determined. Subsequently, salt solutions containing the equivalent cationic concentration found in each of the seaweed extracts were tested on Sprague-Dawley (SD) rats. All seaweeds investigated produced significant (P < 0.05) reductions in the blood pressure of both SHR and the control WKY rats. In T. ornata, significant (P < 0.05) HR reducing effect was produced. In contrast, this effect was not seen in other brown seaweeds tested. Analysis of the ionic composition present in all the extracts revealed that the salt solution with equivalent ionic content of each seaweed extract did not produce any significant decrease in blood pressure of the SD rats. In conclusion, the data obtained from the present study suggest that the aqueous extracts of T. ornata, Sargassum sp. and P. tetrastromatica may contain blood pressure lowering agents. 

© 2016 The Authors. Published by IASE.

This is an open access article under the CC BY-NC-ND license (

Keywords: Ant hypertension, Brown seaweeds, Blood pressure, Spontaneously hypertensive rats (SHR)

Article History: Received 22 July 2016, Received in revised form 7 September 2016, Accepted 29 September 2016

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Sabirin F, Soo KK, Ziau HS, and Kuen LS (2016). Antihypertensive effects of edible brown seaweeds in rats. International Journal of Advanced and Applied Sciences, 3(9): 103-109


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