International Journal of Advanced and Applied Sciences

Int. j. adv. appl. sci.

EISSN: 2313-3724

Print ISSN:2313-626X

Volume 3, Issue 7  (July 2016), Pages:  69-74

Title: Analyzing the effect of MicroRNAs on Hepatogenic differentiation of Mesenchymal stem cells

Authors:  Ehsan Jahangirian *, Seyed Moayed Alavian


Baqiyatallah Research Center for Gastroenterology and Liver Disease Baqiyatallah University of Medical Sciences, Tehran, Iran

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This research aims at analyzing the effect of microRNAs on hepatogenic Differentiation of mesenchymal stem cells. According to the results, miR-1246, miR-1290, miR-148a, miR-30a, miR-424 and miR-542-5p were definitely overexpressed during hepatic differentiation of hMSCs. Also the results indicate that ectopic overexpression of miR-122 cannot initiate hepatic differentiation of hMSCs. In other words, hMSCs can be converted into functional hepatocytes only if all the miRs (miR-122, miR-1246, miR-1290, miR-148a, miR-30a, miR-424, and miR-542-5p) are used. 

© 2016 The Authors. Published by IASE.

This is an open access article under the CC BY-NC-ND license (

Keywords: Hepatogenic, Mesenchymal stem cells, MicroRNAs

Article History: Received 18 May 2016, Received in revised form 25 July 2016, Accepted 26 July 2016

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Jahangirian E, Alavian SM (2016). Analyzing the effect of MicroRNAs on Hepatogenic differentiation of Mesenchymal stem cells. International Journal of Advanced and Applied Sciences, 3(7): 69-74


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