International Journal of

ADVANCED AND APPLIED SCIENCES

EISSN: 2313-3724, Print ISSN: 2313-626X

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 Volume 10, Issue 1 (January 2023), Pages: 77-83

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 Original Research Paper

Assessment of the effect of auditory integration therapy on human forkhead box protein J1 and its impact on behavioral, social, and sensory symptoms in children with autism spectrum disorder

 Author(s): Laila Yousef AL-Ayadhi 1, 2, Abdulrahman Mohammed Alhowikan 1, 2, Nadra Elyass Elamin 1, Dost Muhammad Halepoto 1, *

 Affiliation(s):

 1Autism Research and Treatment Center, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
 2Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia

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 * Corresponding Author. 

  Corresponding author's ORCID profile: https://orcid.org/0000-0001-7705-8348

 Digital Object Identifier: 

 https://doi.org/10.21833/ijaas.2023.01.011

 Abstract:

This study aimed to explore the effect of auditory integration therapy (AIT) on the forkhead box J1 protein and assessed its impact on behavioral, social, and sensory symptoms in children with autism. Behavioral, social, and sensory scores were calculated for each child using the childhood autism rating scale, social responsiveness scale, and short sensory profile before and after AIT. The plasma level of Foxj1 was [575 (351-2553) pg/mL] [median (interquartile range)] before AIT. This level did not change significantly (p˃0.05) immediately [1143(336-4599)], after one month [1268 (275-4932)], or three months [1058 (184-3462)] AIT. However, results revealed that behavioral, social, and sensory rating scales were improved after AIT. Pearson correlation (r) values before and after AIT between severity variables were calculated. Unchanged plasma levels of Foxj1 after AIT supported the non-therapeutic effect of AIT on Foxj1 in autistic children. A significant change in behavioral, social, and sensory symptoms was noticed in autistic children. Additional research, on a large population, is necessary to assess AIT's impact on behavioral and social changes in children with an autism spectrum disorder.

 © 2022 The Authors. Published by IASE.

 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

 Keywords: Autism spectrum disorder, Human forkhead box protein J1, Childhood autism rating scale, Social responsiveness scale, Short sensory profile

 Article History: Received 16 June 2022, Received in revised form 21 September 2022, Accepted 25 September 2022

 Acknowledgment 

We thank the Autism Research and Treatment Centre, Department of Physiology, Faculty of Medicine, King Saud University. King Abdul Aziz City for Science and Technology (KACST), and Vice Deanship of Research Chairs, at King Saud University, Kingdom of Saudi Arabia for financial support. This project was funded by the National Plan for Science, Technology and Innovation (MAARIFAH), King Abdulaziz City for Science and Technology (KACST), Kingdom of Saudi Arabia (Project No. 08-MED 510-02).

 Compliance with ethical standards

 Conflict of interest: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

 Citation:

 AL-Ayadhi LY, Alhowikan AM, Elamin NE, and Halepoto DM (2023). Assessment of the effect of auditory integration therapy on human forkhead box protein J1 and its impact on behavioral, social, and sensory symptoms in children with autism spectrum disorder. International Journal of Advanced and Applied Sciences, 10(1): 77-83

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 Figures

 Fig. 1 

 Tables

 Table 1 Table 2 

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