International Journal of

ADVANCED AND APPLIED SCIENCES

EISSN: 2313-3724, Print ISSN: 2313-626X

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 Volume 9, Issue 6 (June 2022), Pages: 79-85

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 Original Research Paper

 Aqueous solubility of high concentrated caffeine using hydrotrope and the application to the anti-cellulite cosmetics

 Author(s): Su In Park 1, Kwang Won Lee 1, Shinsung Park 2, Moon Sam Shin 2, *, Beom Seok Park 3

 Affiliation(s):

 1Department of Senior Healthcare Majoring in Cosmetic Formulation and Pharmacology, Eulji University, Seongnam, South Korea
 2Department of Beauty and Cosmetic Science, Eulji University, Seongnam, South Korea
 3Department of Clinical Pathology, Eulji University, Seongnam, South Korea

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 * Corresponding Author. 

  Corresponding author's ORCID profile: https://orcid.org/0000-0002-3083-8950

 Digital Object Identifier: 

 https://doi.org/10.21833/ijaas.2022.06.010

 Abstract:

This study presents measurements of the aqueous solubility of caffeine at a temperature ranging from 5 to 40°C. And the low water solubility of caffeine was increased by using a hydrotropic solubilization system. Solubility was measured with a single hydrotropic system of niacinamide or betaine and a mixed hydrotropic system of niacinamide and betaine. As a result, it was possible to prepare a high-concentration aqueous caffeine solution of about 4% at 5.9°C and about 25% at 39.9°C. The modified Apelblat equation was applied to predict the temperature dependence of caffeine solubility in aqueous solutions containing niacinamide, and our experimental data showed good agreement with the correlated values. We propose the results of this study as basic data for the development of anti-cellulite cosmetics. 

 © 2022 The Authors. Published by IASE.

 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

 Keywords: Caffeine, Solid-liquid equilibrium, Hydrotropic solubilization system, Niacinamide, Betaine, Anti-cellulite cosmetics

 Article History: Received 16 December 2021, Received in revised form 27 March 2022, Accepted 30 March 2022

 Acknowledgment 

This study was supported by the Bio and Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science and ICT (2017M3A9D8048416).

 Compliance with ethical standards

 Conflict of interest: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

 Citation:

 Park SI, Lee KW, and Park S et al. (2022). Aqueous solubility of high concentrated caffeine using hydrotrope and the application to the anti-cellulite cosmetics. International Journal of Advanced and Applied Sciences, 9(6): 79-85

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 Figures

 Fig. 1 Fig. 2 Fig. 3 Fig. 4 

 Tables

 Table 1 Table 2 Table 3 Table 4 Table 5 Table 6

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