International Journal of

ADVANCED AND APPLIED SCIENCES

EISSN: 2313-3724, Print ISSN: 2313-626X

Frequency: 12
line decor
  
line decor

 Volume 9, Issue 5 (May 2022), Pages: 86-89

----------------------------------------------

 Original Research Paper

 Title: Nano-emulsion system consisting of non-ionic surfactant, silicone, and polyol

 Author(s): Su In Park 1, Jinseo Lee 1, Kwang Won Lee 1, Shinsung Park 2, Moon Sam Shin 2, *

 Affiliation(s):

 1Department of Senior Healthcare Majoring in Cosmetic Formulation and Pharmacology, Eulji University, Seongnam, South Korea
 2Department of Beauty and Cosmetic Science, Eulji University, Seongnam, South Korea

  Full Text - PDF          XML

 * Corresponding Author. 

  Corresponding author's ORCID profile: https://orcid.org/0000-0002-3083-8950

 Digital Object Identifier: 

 https://doi.org/10.21833/ijaas.2022.05.011

 Abstract:

This study aimed to evaluate the optimum formulation of a niosomal nano-emulsion system consisting of silicone oil, non-ionic surfactant, and polyol. The nano-emulsions were prepared through a two-step homogenization procedure by a homogenizer and microfluidizer. The experiments were carried out by changing the composition ratio of dimethicone (DC200/100cs), polyglyceryl-2 dioleate, and glycerin, respectively. The variation of dimethicone resulted in showing a tendency for the content and particle size to be proportional. The variation of polyglyceryl-2 dioleate and the glycerin variation resulted in showing a similar tendency of the content and particle size to be inversely proportional. In zeta potential measurement, all nano-emulsions marked absolute value over around 30 mV, which is considered to be stable, while no significant correlation was observed with the variation. Based on these verifications, the author proposes the optimal conditions for preparing niosomal nano-emulsions. 

 © 2022 The Authors. Published by IASE.

 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

 Keywords: Nano-emulsion, Dimethicone, Polyglyceryl-2 dioleate, Particle size, Zeta-potentia

 Article History: Received 14 December 2021, Received in revised form 23 February 2022, Accepted 5 March 2022

 Acknowledgment 

This study was supported by the Bio and Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science and ICT (2017M3A9D8048416).

 Compliance with ethical standards

 Conflict of interest: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

 Citation:

 Park SI, Lee J, and Lee KW et al. (2022). Nano-emulsion system consisting of non-ionic surfactant, silicone, and polyol. International Journal of Advanced and Applied Sciences, 9(5): 86-89

 Permanent Link to this page

 Figures

 Fig. 1 Fig. 2 Fig. 3

 Tables

 Table 1

----------------------------------------------    

 References (15)

  1. Alsohaimi IH, Khan MR, Ali HM, Azam M, and Alammari AM (2020). Solvent extraction and gas chromatography–mass spectrometric determination of probable carcinogen 1, 4-dioxane in cosmetic products. Scientific Reports, 10: 5214. https://doi.org/10.1038/s41598-020-62149-x   [Google Scholar] PMid:32251326 PMCid:PMC7090059
  2. Bartelds R, Nematollahi MH, Pols T, Stuart MC, Pardakhty A, Asadikaram G, and Poolman B (2018). Niosomes, an alternative for liposomal delivery. PLOS ONE, 13(4): e0194179. https://doi.org/10.1371/journal.pone.0194179   [Google Scholar] PMid:29649223 PMCid:PMC5896898
  3. Fernandez P, André V, Rieger J, and Kühnle A (2004). Nano-emulsion formation by emulsion phase inversion. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 251(1-3): 53-58‏. https://doi.org/10.1016/j.colsurfa.2004.09.029   [Google Scholar]
  4. Gupta RK, Varanelli CL, Griffin P, Wallach DF, and Siber GR (1996). Adjuvant properties of non-phospholipid liposomes (Novasomes®) in experimental animals for human vaccine antigens. Vaccine, 14(3): 219-225. https://doi.org/10.1016/0264-410X(95)00182-Z   [Google Scholar]
  5. Halnor VV, Pande VV, Borawake DD, and Nagare HS (2018). Nanoemulsion: A novel platform for drug delivery system. Journal of Materials Science and Nanotechnology, 6(1): 104.   [Google Scholar]
  6. Honary S and Zahir F (2013). Effect of zeta potential on the properties of nano-drug delivery systems-a review (Part 2). Tropical Journal of Pharmaceutical Research, 12(2): 265-273‏. https://doi.org/10.4314/tjpr.v12i2.20   [Google Scholar]
  7. Imran M, Shah MR, Ullah F, Ullah S, Elhissi AM, Nawaz W, and Ali I (2016). Glycoside-based niosomal nanocarrier for enhanced in-vivo performance of Cefixime. International Journal of Pharmaceutics, 505(1-2): 122-132.‏ https://doi.org/10.1016/j.ijpharm.2016.03.042   [Google Scholar] PMid:27050867
  8. Jo YJ and Kwon YJ (2014). Characterization of β-carotene nanoemulsions prepared by microfluidization technique. Food Science and Biotechnology, 23(1): 107-113‏. https://doi.org/10.1007/s10068-014-0014-7   [Google Scholar]
  9. Kazi KM, Mandal AS, Biswas N, Guha A, Chatterjee S, Behera M, and Kuotsu K (2010). Niosome: A future of targeted drug delivery systems. Journal of Advanced Pharmaceutical Technology and Research, 1(4): 374-380.‏ https://doi.org/10.4103/0110-5558.76435   [Google Scholar] PMid:22247876 PMCid:PMC3255404
  10. Knapik R, Dos Santos Taques MCR, Praes C, and De Oliveira LL (2010). Characterizing nanoemulsions prepared by high pressure homogenization under various emulsifying conditions. Cosmetics and Toiletries, 125(3): 72–78.   [Google Scholar]
  11. Kumar N and Mandal A (2018). Oil-in-water nanoemulsion stabilized by polymeric surfactant: Characterization and properties evaluation for enhanced oil recovery. European Polymer Journal, 109: 265-276. https://doi.org/10.1016/j.eurpolymj.2018.09.058   [Google Scholar]
  12. Mahdi Jafari S, He Y, and Bhandari B (2006). Nano-emulsion production by sonication and microfluidization-A comparison. International Journal of Food Properties, 9(3): 475-485‏. https://doi.org/10.1080/10942910600596464   [Google Scholar]
  13. Patel RP and Joshi JR (2012). An overview on nanoemulsion: A novel approach. International Journal of Pharmaceutical Sciences and Research, 3(12): 4640-4650‏.   [Google Scholar]
  14. Rang MJ (2019). Recent trends in research of polyglycerin fatty acid esters. Journal of the Korean Applied Science and Technology, 36(4): 1443-1459‏.   [Google Scholar]
  15. Sagitani H, Ikeda Y, and Ogo Y (1984). Effect of polyols on the association state of nonionic surfactants in aqueous solutions utilization of polyols for increasing the solubilization of oil. Journal of Japan Oil Chemists' Society, 33(3): 156-161‏. https://doi.org/10.5650/jos1956.33.156   [Google Scholar]