International Journal of

ADVANCED AND APPLIED SCIENCES

EISSN: 2313-3724, Print ISSN: 2313-626X

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 Volume 9, Issue 11 (November 2022), Pages: 64-70

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 Review Paper

 Antioxidant and anti-inflammatory activities of bioactive compounds from Crescentia cujete L. leaves and fruit–A review

 Author(s): Alecsanndra L. Gonzales 1, Ureah Thea A. Sevilla 1, Po-Wei Tsai 2, *, Steven Kuan-Hua Huang 2, 3, 4

 Affiliation(s):

 1School of Chemical, Biological, Materials Engineering and Sciences, Mapúa University, Manila, Philippines
 2Department of Medical Sciences Industry, College of Health Sciences, Chang Jung Christian University, Tainan, Taiwan
 3Division of Urology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan
 4School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

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 * Corresponding Author. 

  Corresponding author's ORCID profile: https://orcid.org/0000-0002-1981-5360

 Digital Object Identifier: 

 https://doi.org/10.21833/ijaas.2022.11.007

 Abstract:

Crescentia cujete is one of the plants considered to have medicinal properties and is commonly used for ethnomedical purposes for its antioxidant and anti-inflammatory properties. Despite the plant’s common indigenous uses, a couple of isolation and characterization studies were done and published in the past listing both identified and unidentified compounds found from the plant. However, the number of studies focusing on its pharmacological activities, specifically the antioxidant and anti-inflammatory activities of the bioactive compounds present in the plant along with their mechanism of action is underwhelming and the plant is far from being fully optimized for drug development and pharmacological advancement. Data and information collated for this review were gathered from publications, books, and articles from trusted scientific journals. In this review, available studies focusing on the antioxidant and anti-inflammatory activities of various extracts from C. cujete were collated and established. The most commonly studied part of the plant as well as the grey areas realized from this review regarding the antioxidant and anti-inflammatory activities of the plant consequently suggests the incorporation of in silico studies to help future researchers understand the mechanism of action of the plant’s bioactive compounds that have antioxidant and anti-inflammatory activities which will ensure the continuous and fast-moving advances in the drug-development and pharmacological advancement of C. cujete extracts.

 © 2022 The Authors. Published by IASE.

 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

 Keywords: Antioxidant, Anti-inflammatory, Crescentia cujete, Phytochemicals, Flavonoids

 Article History: Received 5 May 2022, Received in revised form 25 July 2022, Accepted 26 July 2022

 Acknowledgment 

The researchers would like to acknowledge the support of our school’s International Linkages for Research and Development (ILRAD) office as well as Dr. Lemmuel Tayo, my department’s previous head. They allowed the collaboration of our school (MAPUA University) and Dr. PoWei’s (Chang Jung Christian University) despite the pandemic which led to the accomplishment of this paper and the research behind it.

 Compliance with ethical standards

 Conflict of interest: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

 Citation:

 Gonzales AL, Sevilla UTA, Tsai PW, and Huang SKH (2022). Antioxidant and anti-inflammatory activities of bioactive compounds from Crescentia cujete L. leaves and fruit–A review. International Journal of Advanced and Applied Sciences, 9(11): 64-70

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 Tables

 Table 1 Table 2 

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