International Journal of


EISSN: 2313-3724, Print ISSN: 2313-626X

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 Volume 8, Issue 12 (December 2021), Pages: 117-125


 Original Research Paper

 Title: The effects of moxidectin nicotine-conditioned cue on nicotine-seeking behavior in mice

 Author(s): Oruç Yunusoğlu 1, 2, *, Muhammed Hamdi Demirkol 3, Mehmet Berköz 4, Vedat Sağmanlıgil 5, Gökhan Oto 2, Hülya Ozdemir 2


 1Department of Pharmacology, Faculty of Medicine, Bolu Izzet Baysal University, Bolu, Turkey
 2Department of Pharmacology, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey
 3Şanlıurfa Training and Research Hospital, Şanlıurfa, Turkey
 4Department of Biochemistry, Faculty of Pharmacy, Van Yuzuncu Yıl University, Van, Turkey
 5Department of Physiology, Faculty of Veterinary Medicine, Near East University, Nicosia, Northern Cyprus

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 * Corresponding Author. 

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Current pharmacotherapies for nicotine abuse are few and relatively inefficient demonstrating the need for the development of new, effective remedies. Moxidectin is used as an anti-parasitic agent in both animals and humans, it also activates GABA receptors. The objective of the present investigation was to study the effect of moxidectin on nicotine-induced conditioned place preference (CPP) in male Swiss mice. Intraperitoneal (i.p.) route was used for nicotine (0.5mg/kg) administration for a 3-day conditioning program. The influences of moxidectin on the reinforcing characteristics of nicotine were tested in mice given i.p. treatment of moxidectin (5 and 10mg/kg) 30 minutes prior to per nicotine administration. CPP was extinguished by repeated testing, through which conditioned mice were daily given two doses of moxidectin (5 and 10mg/kg, i.p.). Subsequently, the potency of moxidectin in blocking the reinstatement of CPP provoked by priming given low-dose nicotine (0.1mg/kg, i.p.) was also evaluated. Moxidectin treatment illustrated a reserve of acquisition of nicotine-induced CPP. It was reduced priming nicotine-induced reinstatement and accelerated the extinction of CPP.  Relatively nicotine enhanced the locomotor, motor activity but was not statistically significant. In conclusion, the outcomes demonstrate the potential for the development of moxidectin as a new pharmacotherapy for the treatment of nicotine addiction. 

 © 2021 The Authors. Published by IASE.

 This is an open access article under the CC BY-NC-ND license (

 Keywords: Nicotine addiction, Moxidectin, Conditioned place preference

 Article History: Received 19 June 2021, Received in revised form 8 October 2021, Accepted 24 October 2021


The author would like to thank Hatice Dilara Kütük for the technical support in the laboratory studies.

 Compliance with ethical standards

 Conflict of interest: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.


 Yunusoğlu O, Demirkol MH, and Berköz M et al. (2021). The effects of moxidectin nicotine-conditioned cue on nicotine-seeking behavior in mice. International Journal of Advanced and Applied Sciences, 8(12): 117-125

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 Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 Fig. 7


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