International journal of

ADVANCED AND APPLIED SCIENCES

EISSN: 2313-3724, Print ISSN:2313-626X

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 Volume 6, Issue 1 (January 2019), Pages: 68-72

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 Original Research Paper

 Title: Neuro-immunological effects of fluorosis: Current perspectives and future outlook for Saudi Arabia

 Author(s): Abjal P. Shaik 1, *, Abbas H. Alsaeed 1, Asma S. Shaik 1, Vamsee K. Bammidi 2

 Affiliation(s):

 1College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
 2The Unicare Group, Burton-on-Trent, Staffordshire, DE14 3GP, United Kingdom

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 * Corresponding Author. 

  Corresponding author's ORCID profile: https://orcid.org/0000-0001-5541-3986

 Digital Object Identifier: 

 https://doi.org/10.21833/ijaas.2019.01.009

 Abstract:

Fluorosis severely affects the quality of life of people causing metabolic and degenerative disorders. Its alarming upsurge in the recent years is a matter of deep concern and warrants intense research to completely eliminate this food and water borne ailment. Compelling evidence indicates that fluoride produces injury not only to the central nervous system but also to the immune system which is the first line of defense against xenobiotics. Studies have demonstrated that the intelligence of children and animals exposed to high levels of fluoride caused lowered learning ability and memory. Fluoride causes neuronal destruction and synaptic injury by free radical production and lipid peroxidation. Although limited information is available about immunotoxicity, it is hypothesized that fluoride affects cells of humoral and cell mediated immune responses. In addition, fluoride is reported to decrease white blood cell counts. Though there have been prospective studies in the past which elucidated various aspects of fluoride induced toxicity, the exact comprehensive understanding of the molecular and biochemical mechanisms of fluoride on the neuroimmunological processes is still a subject that needs clinical evaluation. Fluorosis is an endemic problem affecting the quality of life of millions in Saudi Arabia. However, only a few studies are conducted in this region. Owing to its alarming upsurge in recent years, it is important to design future studies to evaluate the neurotoxic and immunotoxic potential of fluoride exposure in humans. 

 © 2018 The Authors. Published by IASE.

 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

 Keywords: Fluorosis, Neuro-immunological affects, Current scenario, Saudi Arabia

 Article History: Received 30 August 2018, Received in revised form 18 November 2018, Accepted 20 November 2018

 Acknowledgement:

This work was supported by National Science Technology and Innovation plan NSTIP strategic Arabia technologies programs, project number NPST-11MED1919-02, in the Kingdom of Saudi Arabia.

 Compliance with ethical standards

 Conflict of interest:  The authors declare that they have no conflict of interest.

 Citation:

 Shaik AP, Alsaeed AH, and Shaik AS et al. (2019). Neuro-immunological effects of fluorosis: Current perspectives and future outlook for Saudi Arabia. International Journal of Advanced and Applied Sciences, 6(1): 68-72

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 References (35) 

  1. ADA (2005). Fluoridation facts. American Dental Association. Chicago, Illinois, USA. Available online at: https://www.ada.org   [Google Scholar]
  2. Adedara IA, Ojuade TJD, Olabiyi BF, Idris UF, Onibiyo EM, Ajeigbe OF, and Farombi EO (2017). Taurine ameliorates renal oxidative damage and thyroid dysfunction in rats chronically exposed to fluoride. Biological Trace Element Research, 175(2): 388-395. https://doi.org/10.1007/s12011-016-0784-2   [Google Scholar] PMid:27334436
  3. ATSDR (2013). Fluorides, hydrogen fluoride, and fluorine: Chapter 3, Health Effects. Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services Public Health Service, USA.   [Google Scholar]
  4. Ayoob S and Gupta AK (2006). Fluoride in drinking water: A review on the status and stress effects. Critical Reviews in Environmental Science and Technology, 36(6): 433-487. https://doi.org/10.1080/10643380600678112   [Google Scholar]
  5. Barbier O, Arreola-Mendoza L, and Del Razo LM (2010). Molecular mechanisms of fluoride toxicity. Chemico-Biological Interactions, 188(2): 319-333. https://doi.org/10.1016/j.cbi.2010.07.011   [Google Scholar] PMid:20650267
  6. Bhagavatula P, Levy SM, Broffitt B, Weber‐Gasparoni K, and Warren JJ (2016). Timing of fluoride intake and dental fluorosis on late‐erupting permanent teeth. Community Dentistry and Oral Epidemiology, 44(1): 32-45. https://doi.org/10.1111/cdoe.12187   [Google Scholar] PMid:26198477 PMCid:PMC4718784
  7. Blaylock RL (2007). Fluoride neurotoxicity and excitotoxicity/microglial activation: Critical need for more research. Fluoride, 40(2): 89-92.   [Google Scholar]
  8. Bouasla A, Bouasla I, Boumendjel A, Abdennour C, El Feki A, and Messarah M (2016). Prophylactic effects of pomegranate (Punica granatum) juice on sodium fluoride induced oxidative damage in liver and erythrocytes of rats. Canadian Journal of Physiology and Pharmacology, 94(7): 709-718. https://doi.org/10.1139/cjpp-2015-0226   [Google Scholar] PMid:27124270
  9. Carey CM (2014). Focus on fluorides: Update on the use of fluoride for the prevention of dental caries. Journal of Evidence Based Dental Practice, 14: 95-102. https://doi.org/10.1016/j.jebdp.2014.02.004   [Google Scholar] PMid:24929594 PMCid:PMC4058575
  10. Das S, Maiti R, and Ghosh D (2006). Fluoride-induced immunotoxicity in adult male albino rat: A correlative approach to oxidative stress. Journal of Immunotoxicology, 3(2): 49-55. https://doi.org/10.1080/15476910600631587   [Google Scholar] PMid:18958685
  11. De Vos G, Jerschow E, Liao Z, and Rosenstreich D (2004). Effects of fluoride and mercury on human cytokine response in vitro. Journal of Allergy and Clinical Immunology, 113(2): S66. https://doi.org/10.1016/j.jaci.2003.12.209   [Google Scholar]
  12. Deng H, Kuang P, Cui H, Chen L, Fang J, Zuo Z, and Zhao L (2016). Sodium fluoride induces apoptosis in cultured splenic lymphocytes from mice. Oncotarget, 7(42): 67880-67900. https://doi.org/10.18632/oncotarget.12081   [Google Scholar] PMid:27655720 PMCid:PMC5356527
  13. Dhaar GM (2008). Foundations of community medicine. 2nd Edition, Elsevier, Amsterdam, Netherlands.   [Google Scholar]
  14. Dhar V and Bhatnagar M (2009). Physiology and toxicity of fluoride. Indian Journal of Dental Research, 20(3): 350-355. https://doi.org/10.4103/0970-9290.57379   [Google Scholar] PMid:19884722
  15. EFSA (2013). Scientific opinion on dietary reference values for fluoride. European Food Safety Authority, Parma, Italy.   [Google Scholar]
  16. Eren E, Özturk M, Mumcu EF, and Canatan D (2005). Fluorosis and its hematological effects. Toxicology and Industrial Health, 21(9): 255-258. https://doi.org/10.1191/0748233705th236oa   [Google Scholar] PMid:16463958
  17. FAN (2012). Skeletal fluorosis in India and its relevance to the west. Fluoride Action Network. Available online at: http://fluoridealert.org/articles/india-fluorosis   [Google Scholar]
  18. Gutowska I, Baranowska-Bosiacka I, Goschorska M, Kolasa A, Łukomska A, Jakubczyk K, and Chlubek D (2015). Fluoride as a factor initiating and potentiating inflammation in THP1 differentiated monocytes/macrophages. Toxicology in Vitro, 29(7): 1661-1668. https://doi.org/10.1016/j.tiv.2015.06.024   [Google Scholar] PMid:26119525
  19. Kanduti D, Sterbenk P, and Artnik B (2016). Fluoride: A review of use and effects on health. Materia Socio-Medica, 28(2): 133-137. https://doi.org/10.5455/msm.2016.28.133-137   [Google Scholar] PMid:27147921 PMCid:PMC4851520
  20. Karaoz E, Oncu M, Gulle K, Kanter M, Gultekin F, Karaoz S, and Mumcu E (2004). Effect of chronic fluorosis on lipid peroxidation and histology of kidney tissues in first-and second-generation rats. Biological Trace Element Research, 102(1-3): 199-208. https://doi.org/10.1385/BTER:102:1-3:199   [Google Scholar]
  21. Khairnar MR, Dodamani AS, Jadhav HC, Naik RG, and Deshmukh MA (2015). Mitigation of fluorosis-a review. Journal of Clinical and Diagnostic Research, 9(6): ZE05- ZE09. https://doi.org/10.7860/JCDR/2015/13261.6085   [Google Scholar]
  22. Nayak B, Roy MM, Das B, Pal A, Sengupta MK, Prasad De S, and Chakraborti D (2009). Health effects of groundwater fluoride contamination. Clinical Toxicology, 47(4): 292-295. https://doi.org/10.1080/15563650802660349   [Google Scholar] PMid:19274500
  23. Salgado-Bustamante M, Ortiz-Pérez MD, Calderón-Aranda E, Estrada-Capetillo L, Niño-Moreno P, González-Amaro R, and Portales-Pérez D (2010). Pattern of expression of apoptosis and inflammatory genes in humans exposed to arsenic and/or fluoride. Science of the Total Environment, 408(4): 760-767. https://doi.org/10.1016/j.scitotenv.2009.11.016   [Google Scholar] PMid:19962721
  24. Sharma C, Suhalka P, Sukhwal P, Jaiswal N, and Bhatnagar M (2014). Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence. Pharmacognosy Magazine, 10(37): 61-65. https://doi.org/10.4103/0973-1296.126663   [Google Scholar] PMid:24696547 PMCid:PMC3969660
  25. Shivarajashankara YM and Shivashankara AR (2012). Neurotoxic effects of fluoride in endemic skeletal fluorosis and in experimental chronic fluoride toxicity. Journal of Clinical and Diagnostic Research, 6(4): 740-744.   [Google Scholar]
  26. Siddiqui AA, Al Hobeira H, Mirza AJ, Alshammari AK, Alshammari BA, Alsalwah NH (2017). Dental fluorosis in Saudi Arabia: A review of current literature. Annals of International medical and Dental Research, 3(3):44-49.   [Google Scholar]
  27. Trivedi MH, Verma RJ, Chinoy NJ, Patel RS, and Sathawara NG (2007). Effect of high fluoride water on intelligence of school children in India. Fluoride, 40(3): 178-183.   [Google Scholar]
  28. UNICEF (2008). UNICEF handbook on water quality. United Nations Children’s Fund, New York, USA.   [Google Scholar]
  29. Valdez-Jiménez L, Fregozo CS, Beltrán MM, Coronado OG, and Vega MP (2011). Effects of the fluoride on the central nervous system. Neurología (English Edition), 26(5): 297-300. https://doi.org/10.1016/j.nrl.2010.10.008   [Google Scholar] PMid:21255877
  30. WHO (2002). Environmental health criteria 227: Fluorides. World Health Organization, Geneva, Switzerland.   [Google Scholar]
  31. Xiang Q (2003). Blood lead of children in Wamiao-Xinhuai intelligence study. Fluoride, 36(3): 198-199.   [Google Scholar]
  32. Xiang Q, Liang Y, Chen L, Wang C, Chen B, Chen X, and Shanghai PR (2003). Effect of fluoride in drinking water on children's intelligence. Fluoride, 36(2): 84-94.   [Google Scholar]
  33. Zhang M, Wang A, He W, He P, Xu B, Xia T, and Yang K (2007). Effects of fluoride on the expression of NCAM, oxidative stress, and apoptosis in primary cultured hippocampal neurons. Toxicology, 236(3): 208-216. https://doi.org/10.1016/j.tox.2007.04.007   [Google Scholar] PMid:17537562
  34. Zhang M, Wang A, Xia T, and He P (2008). Effects of fluoride on DNA damage, S-phase cell-cycle arrest and the expression of NF-κB in primary cultured rat hippocampal neurons. Toxicology Letters, 179(1): 1-5. https://doi.org/10.1016/j.toxlet.2008.03.002   [Google Scholar] PMid:18485627
  35. Zhao Y, Hao J, Wang J, and Wang J (2017). Effect of choline on the composition and degradation enzyme of extracellular matrix of mice chondrocytes exposed to fluoride. Biological Trace Element Research, 175(2): 414-420. https://doi.org/10.1007/s12011-016-0787-z   [Google Scholar] PMid:27368532