International journal of

ADVANCED AND APPLIED SCIENCES

EISSN: 2313-3724, Print ISSN:2313-626X

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 Volume 5, Issue 9 (September 2018), Pages: 101-109

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 Original Research Paper

 Title: Structural alteration of motor and sensory cortices in Parkinson’s disease using magnetic resonance imaging: Automatic brain segmentation

 Author(s): Sahar Shareef 1, Tahir Ali 2, Bunyamin Sahin 3, Amani Elfaki 4, Raeesa Abdel Tawab Mohammad 1, Aly Mohamed Ahmed 1, Amal AlRabiah 1, Tahani Ahmad Al-Matrafi 1, Samar Al-Saggaf 5, Abdul-Aziz Haji Ahmed 1, Muhammad Atteya 1, 6, *

 Affiliation(s):

 1Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia
 2Department of Anatomy, Faculty of Medicine, National Ribat University, Khartoum, Sudan
 3Department of Anatomy, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey
 4Department of Anatomy, Faculty of Medicine, National University, Khartoum, Sudan
 5Department of Anatomy, Faculty of Medicine, King Abdul Aziz University, Jeddah, Saudi Arabia
 6Department of Histology, Faculty of Medicine, Cairo University, Cairo, Egypt

 https://doi.org/10.21833/ijaas.2018.09.015

 Full Text - PDF          XML

 Abstract:

Parkinson’s disease (PD) is a neurodegenerative disorder commonly diagnosed as motor triad of symptoms including tremor, rigidity and bradykinesia. The degeneration of the Substantia nigra in PD, leads to alterations in the function of cortical areas including primary motor cortex and other non-primary motor areas. The combination of motor and sensory symptoms marked in PD, is the cause of investigating the structural changes of motor and sensory cortices in PD. The aim of this study is to detect the structural changes of cortical thickness and the volume of grey matter and white matter in motor and sensory cortices in PD. This will help in early detection of the disease, monitor response to medication or help in prognosis and prediction of outcomes. Nineteen control volunteers and 18 Parkinson’s patients were participated in the study. The ages of participants were ranging between 45-65 years (mean 56.14 years). Structural magnetic resonance imaging was performed and the Digital Imaging and Communications in Medicine (DICOM) images were evaluated using automatic brain segmentation software (BrainSuite). The structural changes in the present study were found in the thickness of the motor cortex and in the volume of grey matter (GM) of the sensory cortex. The thickness of the right motor cortex for males was smaller in Parkinson’s patients than control. The volume of the GM of left sensory cortex for males was smaller in Parkinson’s patients than control. While no differences were found between Patients and controls in the volume of GM or white matter (WM) in the motor cortex, or in the volume of WM and the cortical thickness in the sensory cortex. Structural changes in specific areas of the brain may influence specific symptoms. 

 © 2018 The Authors. Published by IASE.

 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

 Keywords: MRI, Parkinson’s disease, Automatic brain segmentation

 Article History: Received 10 May 2018, Received in revised form 19 July 2018, Accepted 27 July 2018

 Digital Object Identifier: 

 https://doi.org/10.21833/ijaas.2018.09.015

 Citation:

 Shareef S, Ali T, and Sahin B et al. (2018). Structural alteration of motor and sensory cortices in Parkinson’s disease using magnetic resonance imaging: Automatic brain segmentation. International Journal of Advanced and Applied Sciences, 5(9): 101-109

 Permanent Link:

 http://www.science-gate.com/IJAAS/2018/V5I9/Shareef.html

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